Call Audio Stream Modification in Android 4.0 ICS

It's technically possible to inject audio into the voice call uplink on some platforms (Qualcomm's MSM8960 and APQ8064, for example). Support exists at the hardware level and at the device driver level. But to make that functionality available to normal applications you'd have to create a custom Android ROM where you've added all the necessary user-space parts in both the Java layers and native layers of Android.

So the short answer is: no, there's no standard way of doing this as an app developer (doesn't matter if you use the SDK or NDK).
If you're working for an OEM or by some other means are able to build and flash your own Android ROMs you can probably get the information you need by asking your platform vendor.

It is very difficult to do so because it relates to handling the Linux Kernal inside the Android OS.

Not only is there no API support , but also the security issue is not allowed to do so.

As being a professional in the software engineering field especially the programmers, wenever assume anyone's success on invention and the related project is valid until the project is being tested.

Also streaming the audio during the call may invoke the issue of privacy and security issue among the smartphone users and the service provider of telephony