Pros

Using well-defined types makes the code far easier and safer to port, as you won't get any surprises when for example one machine interprets int as 16-bit and another as 32-bit. With stdint.h, what you type is what you get.

Using int etc also makes it hard to detect dangerous type promotions.

Another advantage is that by using int8_t instead of char, you know that you always get a signed 8 bit variable. char can be signed or unsigned, it is implementation-defined behavior and varies between compilers. Therefore, the default char is plain dangerous to use in code that should be portable.

If you want to give the compiler hints of that a variable should be optimized, you can use the uint_fastx_t which tells the compiler to use the fastest possible integer type, at least as large as 'x'. Most of the time this doesn't matter, the compiler is smart enough to make optimizations on type sizes no matter what you have typed in. Between sequence points, the compiler can implicitly change the type to another one than specified, as long as it doesn't affect the result.

Cons

None.

Reference: MISRA-C:2004 rule 6.3."typedefs that indicate size and signedness shall be used in place of the basic types".

EDIT : Removed incorrect example.

The only reason to use uint8_t rather than unsigned char (aside from aesthetic preference) is if you want to document that your program requires char to be exactly 8 bits. uint8_t exists if and only if CHAR_BIT==8, per the requirements of the C standard.

The rest of the intX_t and uintX_t types are useful in the following situations:

• reading/writing disk/network (but then you also have to use endian conversion functions)
• when you want unsigned wraparound behavior at an exact cutoff (but this can be done more portably with the & operator).
• when you're controlling the exact layout of a struct because you need to ensure no padding exists (e.g. for memcmp or hashing purposes).

On the other hand, the uint_least8_t, etc. types are useful anywhere that you want to avoid using wastefully large or slow types but need to ensure that you can store values of a certain magnitude. For example, while long long is at least 64 bits, it might be 128-bit on some machines, and using it when what you need is just a type that can store 64 bit numbers would be very wasteful on such machines. int_least64_t solves the problem.

I would avoid using the [u]int_fastX_t types entirely since they've sometimes changed on a given machine (breaking the ABI) and since the definitions are usually wrong. For instance, on x86_64, the 64-bit integer type is considered the "fast" one for 16-, 32-, and 64-bit values, but while addition, subtraction, and multiplication are exactly the same speed whether you use 32-bit or 64-bit values, division is almost surely slower with larger-than-necessary types, and even if they were the same speed, you're using twice the memory for no benefit.

Finally, note that the arguments some answers have made about the inefficiency of using int32_t for a counter when it's not the native integer size are technically mostly correct, but it's irrelevant to correct code. Unless you're counting some small number of things where the maximum count is under your control, or some external (not in your program's memory) thing where the count might be astronomical, the correct type for a count is almost always size_t. This is why all the standard C functions use size_t for counts. Don't consider using anything else unless you have a very good reason.

cons

The primary reason the C language does not specify the size of int or long, etc. is for computational efficiency. Each architecture has a natural, most-efficient size, and the designers specifically empowered and intended the compiler implementor to use the natural native data size data for speed and code size efficiency.

In years past, communication with other machines was not a primary concern—most programs were local to the machine—so the predictability of each data type's size was of little concern.

Insisting that a particular architecture use a particular size int to count with is a really bad idea, even though it would seem to make other things easier.

In a way, thanks to XML and its brethren, data type size again is no longer much of a concern. Shipping machine-specific binary structures from machine to machine is again the exception rather than the rule.