Target WSGI script cannot be loaded as Python module

For me the problem was wsgi python version mismatch. I was using python 3, so:

$ sudo apt-get remove libapache2-mod-python libapache2-mod-wsgi$ sudo apt-get install libapache2-mod-wsgi-py3

Warning from @alxs before you copy/paste these commands:
If there are python 2 projects running on the server that use wsgi and apache, the above commands will effectively shut them down.

For me the issue was that the WSGI script wasn't executable.

sudo chmod a+x django.wsgi

or just

sudo chmod u+x django.wsgi

so long as you have the correct owner

I had a similar problem with this error message in the logs:

Target WSGI script '/home/web2py/wsgihandler.py' cannot be loaded as Python module.

The solution was the deletion of an incorrect WSGIPythonHome directive (pointing to the application directory) from /etc/httpd/conf.d/wsgi.conf

I'm on RedHat using CentOS repositories.

Recommend following Graham Dumpleton's installation/configuration instructions. Testing configuration against the helloworld application showed me that mod_wsgi was working and the configuration was at fault.

However, the error message gave little clue as to what was wrong.