Based on my experience, there are two possible causes.

VPC Link

If your origin server is inside private VPC, it is necessary to create VPC Link and Network Load Balancer (NLB) instead of Application Load Balancer (ALB).

See more detail: https://docs.aws.amazon.com/apigateway/latest/developerguide/set-up-private-integration.html

Point to API Gateway Endpoint

CNAME should point to the API Gateway endpoint instead of CloudFront. In this case, the value of CNAME should be like this.

https://[api-id].execute-api.[region].amazonaws.com

Otherwise, the access through the custom domain is passed directly to the CloudFront.

(Another Possible Cause) Using A Record

In my case, A record is used to point to the alias of NLB. It is a functionality of Route53 but using A record might be necessary instead of CNAME.

The "Cannot GET" error code is not a Lambda or API Gateway error code, and looks specific to Express JS.

The logs you've posted look like lambda logs, and if so then either lambda is getting invoked by something else, or you have successfully invoked your lambda function via the API call using "https://apis.mydomain.com/aprod/api/v1/todos" as user "Sándor Bakos" suggested.

This means that you aren't dealing with a custom domain or API Gateway error, but instead are seeing this error from your Lambda function code. Some quick googling proves that out and I wonder if this SO post will help?Node, Express - CANNOT GET route

For a bit more detail, if you were to invoke an URI in API Gateway that doesn't exist, unless you are successfully using SIGV4(IAM Auth) you will get a 403 with error message "Missing Authentication Token", and even then it would not return a "Cannot GET" error message unless you specifically mapped a gateway response for it.