Flask Response vs Flask make_response
make_response() gives you a convenience interface, one that will take arguments in more formats than the flask.Response() object takes.
In addition, make_response() uses the Flask.response_class attribute (so app.response_class) to build the response. The default value for Flask.response_class is flask.Response, but you can set this value to a subclass instead.
So you should really always use make_response(), rather than use flask.Response() directly, especially if you want to support swapping out what Response class you actually use for responses.
You may have to use app.response_class directly if it is a subclass that takes arguments that make_response() can't supply.