Simplest way to deploy platform independent python apps with graphics functionality. [closed]
Two thought on your question.
Have you thought about building in using pyjamas. You could then package it for the desktop using pyjamasdesktop and get the best of both worlds. If you want to run it online you can, but if you want to make it available offline, it is a fairly simple transition.
The interface will be web based, so, you will not have access to all of the robustness of Tkinter. However, you trade that for flexibility.pyinstaller will let you create packaging formats for both the mac and the windows platform. This way you do not have to learn two separate tools to package your application.