Python Win32 send keystrokes to Chrome
You can use this
import pyautoguipyautogui.hotkey('f5')
This will simulate your refresh key, sending the signal to chrome.
In case you don't want the chrome window to be made active, then when you START chrome, start it by typing this in the command prompt:
start /B chrome.exe
Then close chrome. It will run in the background. When the work is done, go Task Manager and close chrome.
OR you could go to Chrome>Advanced>System and see the first option.