Is iOS6 simulator buggy when deleting applications?

I've run into this as well and it only seems to be a problem for me when I have the simulator set to version = iOS 5.0 or iOS 5.1. In any case, what I did to delete my app w/o completely resetting the simulator is the following:

1. Quit iOS Simulator
2. In the Finder or Terminal, go to ~/Library/ApplicationSupport/iPhone Simulator/5.1
3. Delete the folder containing the app you want to remove from the simulator
4. Restart the simulator (or just Build + Run from XCode) and your app gone/freshly installed

In step #2, replace "5.1" with the iOS simulator version you want to remove your app from.

The OP mentioned that this solution didn't work. My guess is they did not do step #1. If you don't quit the simulator first, deleting the app folder may not be possible if the app is running in the simulator and won't visually show up until a restart anyway.

You can reset you simulator configuration from iOS Simulator-> Reset Content and Settings...This will delete all your data on simulator

I have this problem with iPhone/iPad 6.0 simulator. I have Lion and xcode 4.5.2 .The way I solved it was after clicking on the X, to use menu to invoke slide to lock, then unlock it. Then the delete msg box will appear and I can confirm the delete.

I sometimes had to rotate left or right before slide to lock would show after invoking the menu.