Best way to obfuscate an e-mail address on a website?
I encode the characters as HTML entities (something like this). It doesn't require JS to be enabled and seems to have stopped most of the spam. I suppose a smart bot might still harvest it, but I haven't had any problems.
Personally, I've given up on hiding my email address. I find it easier to look into better spam-filtering solutions than worry about obfuscating. You could spend days trying to find the best way to obfuscate your address, and then all it takes is one person to sell your address to a spammer and all that work was useless.
The current accepted solution is to create a contact form that allows users to email you. If you receive a lot of spam from that (I don't on my site), then you can add a captcha for good measure, and you'll be far from the "low hanging fruit" at that point.
The fact of the matter is that if you are providing a link that a user can click on to pop open their email client with your address in the To: field, then the computer is able to decipher the email address from the page and so can a spam bot.