Difference between uwsgi_pass and proxy_pass in Nginx?
uwsgi_pass uses an uwsgi protocol. proxy_pass uses normal HTTP to contact with uWSGI server. uWSGI docs claims that this protocol is better, faster and can benefit from all of uWSGI special features.
Are there any real benefits? Yes. You can send to uWSGI information what type of data you are sending and what uWSGI plugin should be invoked to generate response. With http (proxy_pass) you won't get that. More on that you can find in uWSGI docs.
But even if there aren't any documented benefits of using uwsgi protocol instead of http for you, you should use uwsgi protocol if you can, because uwsgi is the main protocol of uWSGI server and it just fits better here.
If you want to use uwsgi protocol you must change http-socket parameter in uWSGI start script to socket.