Sound not working in iPhone Simulator?
On your Mac, go to System Preferences > Sound > Sound Effects and then uncheck and recheck "Play user interface sound effects".
You need to re-activate your system sounds, see the end of this page.
I had no sound in the simulator, so I tested it with mobile safari and tried playing an mp3: No sound!
All the above tips didn't help. Eventually, I changed my INPUT source from the virtual soundflower device to Line-In, and the Simulator worked!
So, even if the app wasn't using input, it didn't work well with Soundflower.
I've seen this problem after my update from OSX10.5.7 to 10.6.2
And I made the following changes to make the simulater sing again:Goto "Applications/Utilities" and run "Audio MIDI Setup", then change midi format from 48000 to 44100.