glob exclude pattern
The pattern rules for glob are not regular expressions. Instead, they follow standard Unix path expansion rules. There are only a few special characters: two different wild-cards, and character ranges are supported [from pymotw: glob – Filename pattern matching].
So you can exclude some files with patterns.
For example to exclude manifests files (files starting with _) with glob, you can use:
files = glob.glob('files_path/[!_]*')
You can't exclude patterns with the glob function, globs only allow for inclusion patterns. Globbing syntax is very limited (even a [!..] character class must match a character, so it is an inclusion pattern for every character that is not in the class).
You'll have to do your own filtering; a list comprehension usually works nicely here:
files = [fn for fn in glob('somepath/*.txt') if not os.path.basename(fn).startswith('eph')]