How can I access Amazon DynamoDB via Python?
Another alternative is PynamoDB. PynamoDB provides an ORM like interface to DynamoDB and supports both Python 2 and Python 3. The entire DynamoDB API is supported by PynamoDB - including global and local secondary indexes, batch operations, binary attributes, queries, scans, etc.
Disclaimer: I wrote PynamoDB.
Disclaimer: I'm the current maintainer
You can use Dynamodb-mapper Python library. It's a simple/tiny abstraction layer that allows you to map plain Python object to DynamoDB. It also features a transaction engine.
For advanced tasks such as table management it is still better to directly use Boto (which we rely on, anyway).