Checkbox using xpath not accessible
You got it correct the element is inside iframe you need to switch it first.
Induce WebDriverWait() and wait for frame_to_be_available_and_switch_to_it()Induce WebDriverWait() and wait for element_to_be_clickable()
WebDriverWait(driver, 10).until(EC.frame_to_be_available_and_switch_to_it((By.CSS_SELECTOR, "iframe#embeddedIframe"))) WebDriverWait(driver, 10).until(EC.element_to_be_clickable((By.XPATH, "//td[.//label[contains(., 'Cooperative Agreement')]]/input[1]"))).click()#Jump out from iframedriver.switch_to.default_content()You need to import below libraries.
from selenium.webdriver.common.by import Byfrom selenium.webdriver.support.ui import WebDriverWaitfrom selenium.webdriver.support import expected_conditions as EC