Multiple SQLite database instances open at the same time on different Threads (QT)

Having multiple connection is not a problem, the only thing to keep in mind is that SQLite does not support concurrency of multiple write transactions. From the SQlite site:

SQLite supports an unlimited number of simultaneous readers, but it will only allow one writer at any instant in time. For many situations, this is not a problem. Writer queue up. Each application does its database work quickly and moves on, and no lock lasts for more than a few dozen milliseconds. But there are some applications that require more concurrency, and those applications may need to seek a different solution.

SQLite is an "untypical" database management system: in practice it is a library that offers SQL as language to access a simple "database-in-a-file", and a few other functionalities of DBMSs. For instance, it has no real concurrency control (it uses the Operating Systems functions to lock the db file).

So, if you need concurrent insertions into a database, you should use something else, for instance PostgreSQL.

The documentation say:

A connection can only be used from within the thread that created it. Moving connections between threads or creating queries from a different thread is not supported.

In addition, the third party libraries used by the QSqlDrivers can impose further restrictions on using the SQL Module in a multithreaded program. Consult the manual of your database client for more information.

It is mean you have to create connection to database which will be linking with parent thread. At docs of QSqlDatabase class you can see description:

The QSqlDatabase class represents a connection to a database.

The QSqlDatabase class provides an interface for accessing a database through a connection. An instance of QSqlDatabase represents the connection. The connection provides access to the database via one of the supported database drivers, which are derived from QSqlDriver.

Create a connection (i.e., an instance of QSqlDatabase) by calling one of the static addDatabase() functions, where you specify the driver or type of driver to use (i.e., what kind of database will you access?) and a connection name.

Using static addDatabase() function is way to create connection.

But as Renzo said SQLite does not support multiple write transactions at the same time. So you need some mechanisms(wrapper) for synchronizing threads like task queue using low-level mutex or something like that. More information you can see at docs.