As a developer, what changes do you make to a vanilla Windows install?
Indeed I do the above, plus deactivating Zip support (regsvr32 /u zipfldr.dll), activating the underscore on Alt shortcuts (Advanced Appearance), replacing Courier New by Andale Mono (replace with your favorite font) in all program settings (after installing it, of course), installing my favorite utilities (UnxUtils, Sysinternals', SciTE, FileMenu Tools which has Command line here and lot of other goodies, etc.) and so on.
Oh, and indeed also deactivate dual keyboard support (French/English), deactivate task grouping, install VirtuaWin (4 desktops), CLCL (clipboard manager), AutoHotkey and my favorite macros, and lot of other freewares, more or less must have.
No automation, alas.
I install: