Mac keyboard shortcuts not working on iOS Simulator
You might have enabled (checked) the "Send all keyboard shortcuts to device" mode. It's in the Hardware > Keyboard submenu.
Pressing both Left and Right Cmd keys at the same time will exit keyboard capturing mode and re-enable menu shortcuts.
You might have disabled(unchecked) "Connect hardware keyboard" option which is in the hardware/keyboard menu. Make sure its checked.
You may need to press the esc key on newer versions of the simulator.You can also choose which key stops shortcut capture.